Inflammation: The Root of All Health and Mental Health Imbalance

February 19, 2025

by Daniel Breeyear, MSN, APRN, PMHNP-BC, BHCC, FMHC
Owner and Director of Care at The Eden Center for Integrative Care

“Remission is the only goal of treatment—not something to merely hope for, but the only acceptable outcome.To reach it, we must confront the deeper layers of our condition—not just the what, but the why—because only by understanding the origins can we begin to transform the whole.”
— Daniel Breeyear Eden Center Founder/Director of Care

In our fast-paced world, achieving mental clarity has become increasingly important for our overall well-being. The faster the world moves, the more the distractions and demands of modern life can leave us feeling overwhelmed and disconnected.

🔥 Inflammation: The Root of All Health and Mental Health Imbalance

When we explore the foundation of true health—both physical and mental—we find one common denominator time and time again: inflammation.

Inflammation, especially when chronic and unresolved, disrupts every system in the body. It hijacks the brain’s chemistry, impairs neurotransmitter production, weakens resilience, and creates the perfect storm for emotional and physical disorders to emerge.

At The Eden Center for Integrative Care, this is one of the first things we assess—because until inflammation is addressed, balance remains out of reach.

🌡️ Always Stress Before Depressed

Depression doesn't just appear out of thin air. There’s almost always a stress load that precedes it. And where there's chronic stress, there is chronic inflammation.

But here’s what’s essential to understand: every individual has a unique capacity to manage inflammation and stress. That capacity is shaped by:

  • Genetic makeup

  • Early life experiences

  • Current lifestyle

  • Gut health

  • Immune system function

  • Sleep, nutrition, and more

Some people may handle immense stress and never fall ill. Others may experience even moderate stress and spiral into fatigue, anxiety, or depression. The key is not in judging the experience but in understanding the biological foundation behind it.

🧠 Inflammation & Neurotransmitter Disruption

One of the most powerful impacts of inflammation is what it does to neurotransmitter synthesis.

For example:

  • The tryptophan pathway, which supports serotonin production, is disrupted in the presence of high inflammation. Instead of being converted to serotonin, tryptophan gets rerouted toward neurotoxic metabolites.

  • The same applies to dopamine, acetylcholine, and others—each of which plays a vital role in mood, cognition, and motivation.

This is why healthy individuals without major stress or trauma can still become depressed if they are exposed to a strong inflammatory trigger—such as an inflammatory substance delivered via IV. In clinical studies, these individuals experienced rapid depressive symptoms, despite no prior mental health history.

Inflammation literally blocks the body's ability to feel well.

🧘 Therapy, Stress & Biological Truth

Therapy and mindset work can teach us how to cope with stressors—but if the underlying inflammatory storm is not addressed, progress can be limited.

Mental health isn’t just a matter of thoughts—it’s biology.

The “it’s all in your head” approach is outdated. Mental wellness depends on inflammation, neurochemistry, gut integrity, hormone balance, and more. That’s why we look at mental health through an integrative lens—and always begin with the inflammatory system.

🔄 The Mind-Body Connection, Explained

It’s not a metaphor—it’s science. The body is one integrated organism.

Inflammation explains why:

  • Chronic illness and mental health symptoms go hand-in-hand

  • Fatigue and mood swings often follow poor diet or illness

  • Immune system flares lead to emotional dysregulation

If the inflammatory system is out of balance, nothing in the body can achieve true homeostasis.

🌿 Final Thoughts

Inflammation is the “invisible fire” that fuels physical breakdown and mental health struggles. It is not a secondary concern—it is the concern. Until inflammation is identified and addressed, the rest is just symptom management.

At The Eden Center for Integrative Care, our work begins with the root cause. And inflammation is often the deepest root of all.

Looking for answers beneath the surface of anxiety, depression, or chronic symptoms? Let’s start at the root.